Chemoenzymatic synthesis of the alarm pheromone (+)-verbenone from geranyl diphosphate.
نویسندگان
چکیده
The enzyme-guided asymmetric synthesis of (+)-verbenone from geranyl diphosphate in a simple two-step, one pot transformation highlights the potential of chemoenzymatic procedures for the generation of high-value terpenoids.
منابع مشابه
Chemoenzymatic synthesis of the alarm pheromone (+)-verbenone from geranyl diphosphatew
With more than 30 000 known members, terpenoids constitute the largest and most structurally diverse family of natural products. Monoterpenes are often found in natural, renewable extracts such as turpentine and are a source of commercially valuable synthetic fragrances, flavours, drugs, agrochemicals and synthetic building blocks. Plant derived terpenoids have diverse biological functions in c...
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Geranyl diphosphate synthase (GPPS) catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to form geranyl diphosphate. Geranyl diphosphate is the precursor of monoterpenes, a large family of natural occurring C(10) compounds predominantly found in plants. Similar to plants but unique to animals, some bark beetle genera (Coleoptera: Scolytidae) produce monoterpenes ...
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 56 شماره
صفحات -
تاریخ انتشار 2012